Neurodegenerative Erkrankungen

Laut Wikipedia:

Als neurodegenerative Erkrankungen (griechisch νέυρο-, néuro-, „Nerv[en]-" und lateinisch dēgenerāre, „aus-" oder „entarten") bezeichnet man eine Gruppe von meist langsam fortschreitenden, erblichen oder sporadisch auftretenden Erkrankungen des Nervensystems. Hauptmerkmal ist der fortschreitende Verlust von Nervenzellen (Neurodegneration), der zu verschiedenen neurologischen Symptomen – darunter häufig zu Demenz und Bewegungsstörungen – führt. Die Erkrankungen können in unterschiedlichen Lebensaltern auftreten, verlaufen diffus oder generalisiert und rufen charakteristische histologische Schädigungsmuster hervor.

Quelle: Brunn A: Vorlesung allgemeine Pathologie, Abteilung für Neuropathologie, Universität zu Köln, Sommersemester 2005

Zitatquelle: http://de.wikipedia.org/wiki/Neurodegenerative_Erkrankung

Neurogenerative Erkrankungen sind u. v. a. z. B.:

  • Morbus Alzheimer (AD)
  • Morbus Parkinson (PD)
  • Multisystematrophie (MSA)
  • Creutzfeldt-Jakob-Krankheit
  • Amyotrophe Lateralsklerose (ALS)
  • Demenzerkrankungen

 


 

Literatur zur Rolle von Schadstoffen bei neurodegenerativen Erkrankungen

 


Quecksilber: eine mögliche Ursache für Alzheimer Demenz

(15.11.2010) Quecksilber könnte eine der verschiedenen Ursachen von Alzheimer Demenz sein. Das ist das Ergebnis einer systematischen Literaturübersicht die am 15.November im Journal of Alzheimer’s Disease publiziert wurde. Forscher von der Europa-Universität Viadrina, dem Samueli Institut, der Northeastern University, Boston und ehemals an der Universitätsklinik Freiburg sichteten die gesamte experimentelle und klinische Literatur systematisch. 

Quecksilber ist eine der giftigsten natürlich vorkommenden Substanzen. Es ist gefährlich für Menschen und könnte zu neurodegenerativen Krankheiten wie Alzheimer Demenz führen, weil es bei Raumtemperatur verdampft und als Gas aufgenommen wird. So gelangt es über Nase und Blut direkt ins Gehirn. Quecksilber kann die Blut-Hirnschranke ungehindert passieren und wird innerhalb des Gehirns festgehalten. Dort kann es sich über die Lebenszeit hinweg ansammeln. 

Richard Deth, einer der Koautoren, stellte ein Modell vor, in dem die Wirkweisen von Quecksilber mit den wichtigsten Zeichen der Alzheimer Erkrankung kausal verknüpft wird. Quecksilber bindet sich fest an Selen. Selenhaltige Proteine gehören zu einer Klasse von Molekülen die der Körper verwendet um Schaden, der durch Stoffwechselprozesse im Gehirn entsteht, den sog. oxidativen Stress, abzufangen. Dieser führt zu Alterung und schließlich Tod der Zelle. Wenn Quecksilber sich an Selen bindet, werden diese Prozesse beschleunigt. 

Die Form des Quecksilbers, die untersucht wurde ist das metallische Quecksilber, das z.B. kontinuierlich von Amalgamfüllungen in Zähnen ausdampft. Solche Amalgamfüllungen enthalten 50% Quecksilber und Menschen mit solchen Füllungen nehmen etwa 1-22 Mikrogramm Quecksilber pro Tag auf. Das meiste davon wird in den Körper und ins Gehirn aufgenommen und verbleibt dort. Das ist mehr als zehnmal soviel Quecksilber als durch regelmäßiges Essen von Fisch aufgenommen wird. Milliarden von Menschen haben solche Amalgamfüllungen und haben deswegen ein erhöhtes Risiko für giftige Folgeschäden. 

Die experimentelle Forschung an Tieren und Zellmodellen kann alle Zeichen der Alzheimer Demenz reproduzieren. Studien über niedrig-dosierte Exposition, etwa bei Zahnärzten zeigen, dass Quecksilber zu kognitiven Einbussen führt. Allerdings fehlen gute Langzeitstudien. Die Situation ist ähnlich wie die bezüglich der Schädlichkeit von Rauchen zu Beginn der 70er Jahre: es gab genügend experimentelle Befunde, aber klinische Studien am Menschen waren unklar. Zu warten bis die Beweislage absolut wasserdicht ist, sei die falsche Strategie, meinen die Forscher, angesichts dessen, was wir alles über die Giftigkeit von Quecksilber wissen. Anorganisches, metallisches Quecksilber sollte aus unseren ökologischen Kreisläufen entfernt werden, um Alzheimer Demenz zu verhüten.

Quelle: Pressemitteilung 15.11.2010, Europa-Universität Viadrina;

http://www.europa-uni.de

Originalarbeit:

Joachim Mutter, Annika Curth, Johannes Naumann, Richard Deth, Harald Walach: Does Inorganic Mercury Play a Role in Alzheimer’s Disease? A Systematic Review and an Integrated Molecular Mechanism Journal of Alzheimer’s Disease, Vol. 22, No. 2, in press, to be published online 15th November 2010,

Original: http://www.j-alz.com/issues/22/vol22-2.html und

http://www.ncbi.nlm.nih.gov/pubmed/20847438

Kostenlos downzuloaden unter http://iospress.metapress.com

 


 

Umwelt-Medizin-Gesellschaft
18. Jahrgang, Ausgabe 4/2005, S. 257-340

Die Alzheimer-Krankheit: Quecksilber als pathogener Faktor und Apolipoprotein E als Moderator, J. MUTTER, J. NAUMANN, C. SADAGHIANI, R. SCHNEIDER und H. WALACH

http://www.umwelt-medizin-gesellschaft.de/



 

Parkinson'sche Erkrankung eines Landwirts durch Pestizide als Berufskrankheit anerkannt

siehe unter  Recht 

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Nur in Englisch:

Environmental Health Perspectives (ehp)

Ergebnisse der Suche zu "neurogenenerativ disease" auf  http://ehp03.niehs.nih.gov

unter  http://ehp03.niehs.nih.gov/search/simpleSearch.action?query=neurodegenerative+disease

Alle Artikel sind im Abstract und im Filltext kostenlos herunterzuladen

▪    Early Environmental Origins of Neurodegenerative Disease in Later Life Philip J Landrigan, Babasaheb Sonawane, Robert N Butler, Leonardo Trasande, Richard Callan, Daniel Droller
disease (AD), the two most common neurodegenerative ... Early Environmental Origins of Neurodegenerative Disease in Later Life ... neurodegenerative disease paraquat Parkinson disease pesticides Research Article, published 26 Mai 2005  | doi:10.1289/ehp.7571

▪    Neurodegenerative Diseases: An Overview of Environmental Risk Factors Rebecca C Brown, Alan H Lockwood, Babasaheb R Sonawane
Neurodegenerative Diseases: An Overview of Environmental Risk ... Neurodegenerative Diseases: An Overview of Environmental Risk Factors ... are afflicted with neurodegenerative diseases. Because Research Article, published 26 Mai 2005  | doi:10.1289/ehp.7567

▪    Headliners: Neurodegenerative Disease: Inflammatory Enzyme Modulates Motor Neuron Damage in Amyotrophic Lateral Sclerosis Jerry Phelps
News Autoimmune Disease Immunity Biochemistry Neurologic Health Headliners: Neurodegenerative Disease ... Headliners: Neurodegenerative Disease: Inflammatory Enzyme Modulates Motor Neuron Damage in Amyotrophic Lateral Sclerosis ... as Lou Gehrig’s disease. ALS is a progressive News, published 01 Dez 2006  | doi:10.1289/ehp.114-a697

▪    Headliners: Neurological Disease: Neural Protein May Stop the Progression of Alzheimer Disease Jerry Phelps
Headliners: Neurological Disease: Neural Protein May Stop the Progression of Alzheimer Disease Jerry Phelps ... Headliners: Neurological Disease: Neural Protein May Stop the Progression of Alzheimer Disease ... disease (AD), which usually begins after age 60 News, published 01 Jan 2005  | doi:10.1289/ehp.113-a31

▪    ADDLs: A New Explanation for Alzheimer Disease? Kris Freeman
") and other neurodegenerative diseases. They may therefore ... ADDLs: A New Explanation for Alzheimer Disease? ... ADDLs: A New Explanation for Alzheimer Disease News, published 01 Nov 2003  | doi:10.1289/ehp.111-a810

▪    Pesticides and Parkinson’s Disease—Is There a Link? Terry P Brown, Paul C Rumsby, Alexander C Capleton, Lesley Rushton, Leonard S Levy
Pesticides and Parkinson’s Disease—Is There a Link ... Pesticides and Parkinson’s Disease—Is There a Link? ... with the article's original DOI. 2006 Parkinson’s disease (PD) is an idiopathic disease of the nervous system characterized Review, published 07 Sep 2005  | doi:10.1289/ehp.8095

▪    Association of Pesticide Exposure with Neurologic Dysfunction and Disease Freya Kamel, Jane A Hoppin
of other neurodegenerative diseases are limited ... Association of Pesticide Exposure with Neurologic Dysfunction and Disease ... -related neurotoxicity to neurodegenerative disease Review, published 20 Mai 2004  | doi:10.1289/ehp.7135

▪    Developmental Pesticide Models of the Parkinson Disease Phenotype Deborah A Cory-Slechta, Mona Thiruchelvam, Brian K Barlow, Eric K Richfield
disease (PD) is a chronic neurodegenerative condition ... Developmental Pesticide Models of the Parkinson Disease Phenotype ... Developmental Pesticide Models of the Parkinson Disease Research Article, published 26 Mai 2005  | doi:10.1289/ehp.7570

▪    Manganese and Parkinson’s Disease: A Critical Review and New Findings Tomás R Guilarte
and neurodegenerative diseases. In PD and conditions associated ... Manganese and Parkinson’s Disease: A Critical Review and New Findings ... and Parkinson’s Disease: A Critical Review and New Findings Review, published 01 Aug 2010  | doi:10.1289/ehp.0901748

▪    Environmental Exposures and Gene Regulation in Disease Etiology Thea M Edwards, John Peterson Myers
, respiratory diseases, allergies, and neurodegenerative ... Environmental Exposures and Gene Regulation in Disease Etiology ... ) is a neurodegenerative disease that affects more than 1 million people Review, published 21 Mai 2007  | doi:10.1289/ehp.9951

▪    Dopamine Transporter Genetic Variants and Pesticides in Parkinson’s Disease Beate R Ritz, Angelika D Manthripragada, Sadie Costello, Sarah J Lincoln, Matthew J Farrer, Myles Cockburn, Jeff Bronstein
in Parkinson’s Disease Beate R. Ritz 1 2 3 Angelika ... Dopamine Transporter Genetic Variants and Pesticides in Parkinson’s Disease ... influence Parkinson’s disease (PD) risk. Materials Research Article, published 22 Feb 2009  | doi:10.1289/ehp.0800277

▪    Environmental Exposure, Obesity, and Parkinson’s Disease: Lessons from Fat and Old Worms Layla Aitlhadj, Daiana Silva Ávila, Alexandre Benedetto, Michael Aschner, Stephen Richard Stürzenbaum
disorders, and neurodegenerative orders, diseases ... Environmental Exposure, Obesity, and Parkinson’s Disease: Lessons from Fat and Old Worms ... , and neurodegenerative disorders, diseases likely to co-occur Review, published 25 Aug 2010  | doi:10.1289/ehp.1002522

▪    The Role of Early Life Environmental Risk Factors in Parkinson Disease: What Is the Evidence? Giancarlo Logroscino
in neurodegenerative diseases Neuron 40 1 1 2 14527425 ... The Role of Early Life Environmental Risk Factors in Parkinson Disease: What Is the Evidence? ... Origins of Neurodegenerative Disease in Later Life Research Article, published 26 Mai 2005  | doi:10.1289/ehp.7573

▪    Delayed Reaction: The Fetal Basis of Adult Disease, with Deborah Cory-Slechta Ashley Ahearn
Reaction: The Fetal Basis of Adult Disease, with Deborah ... Delayed Reaction: The Fetal Basis of Adult Disease, with Deborah Cory-Slechta ... , cardiovascular disease, cancer, and Parkinson disease—via Podcast, published 01 Jul 2010  | doi:10.1289/ehp.trp070110

▪    Whole-Body Lifetime Occupational Lead Exposure and Risk of Parkinson’s Disease Steven Coon, Azadeh Stark, Edward Peterson, Aime Gloi, Gene Kortsha, Joel Pounds, David Chettle, Jay Gorell
’s Disease Steven Coon 1 Azadeh Stark ... Whole-Body Lifetime Occupational Lead Exposure and Risk of Parkinson’s Disease ... an association between Parkinson’s disease (PD) and exposure Research Article, published 18 Aug 2006  | doi:10.1289/ehp.9102

▪    A Niche for Infectious Disease in Environmental Health: Rethinking the Toxicological Paradigm Beth J Feingold, Leora Vegosen, Meghan Davis, Jessica Leibler, Amy Peterson, Ellen K Silbergeld
for Infectious Disease in Environmental Health: Rethinking ... A Niche for Infectious Disease in Environmental Health: Rethinking the Toxicological Paradigm ... and Infectious Disease Objective: In this review Review, published 01 Aug 2010  | doi:10.1289/ehp.0901866

▪    Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease Hui-Ming Gao, Feng Zhang, Hui Zhou, Wayneho Kam, Belinda Wilson, Jau-Shyong Hong
neurodegenerative processes in Parkinson’s disease (PD)—the second most common neurodegenerative disease—remain elusive ... Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease ... neurodegenerative diseases including PD; and d ) a chronic Research Article, published 18 Jan 2011  | doi:10.1289/ehp.1003013

▪    Parkinson's Disease and Exposure to Infectious Agents and Pesticides and the Occurrence of Brain Injuries: Role of Neuroinflammation Bin Liu, Hui-Ming Gao, Jau-Shyong Hong
neurodegenerative diseases: mechanisms and strategies ... Parkinson's Disease and Exposure to Infectious Agents and Pesticides and the Occurrence of Brain Injuries: Role of Neuroinflammation ... ehp.6361 10.1289/ehp.6361 Parkinson's Disease Review, published 14 Mai 2003  | doi:10.1289/ehp.6361

▪    Meeting Report: Consensus Statement—Parkinson’s Disease and the Environment: Collaborative on Health and the Environment and Parkinson’s Action Network (CHE PAN) Conference 26–28 June 2007 Jeff Bronstein, Paul Carvey, Honglei Chen, Deborah Cory-Slechta, Donato DiMonte, John Duda, Paul English, Samuel Goldman, Stephen Grate, Johnni Hansen, Jane Hoppin, Sarah Jewell, Freya Kamel, Walter Koroshetz, James W Langston, Giancarlo Logroscino, Lorene Nelson, Bernard Ravina, Walter Rocca, George W Ross, Ted Schettler, Michael Schwarzschild, Bill Scott, Richard Seegal, Andrew Singleton, Kyle Steenland, Caroline M Tanner, Stephen Van Den Eeden, Marc Weisskopf
’s disease (PD) is the second most common neurodegenerative ... Meeting Report: Consensus Statement—Parkinson’s Disease and the Environment: Collaborative on Health and the Environment and Parkinson’s Action Network (CHE PAN ... ’s disease (PD) is the second most common neurodegenerative Research Article, published 26 Aug 2008  | doi:10.1289/ehp.11702

▪    Rotenone, Paraquat, and Parkinson’s Disease Caroline M Tanner, Freya Kamel, G Webster Ross, Jane A Hoppin, Samuel M Goldman, Monica Korell, Connie Marras, Grace S Bhudhikanok, Meike Kasten, Anabel R Chade, Kathleen Comyns, Marie Barber Richards, Cheryl Meng, Benjamin Priestley, Hubert H Fernandez, Franca Cambi, David M Umbach, Aaron Blair, Dale P Sandler, J William Langston
, Paraquat, and Parkinson’s Disease Caroline M. Tanner ... Rotenone, Paraquat, and Parkinson’s Disease ... of Parkinson’s disease (PD). Certain pesticides may affect Research Article, published 26 Jan 2011  | doi:10.1289/ehp.1002839

▪    Calculating Your Odds for Disease Barry Schlegel, Laura Hemminger
10.1289/ehp.scied011 10.1289/ehp.scied011 Science Education | Disease Science Education | Disease Calculating Your Odds for Disease Barry Schlegel Laura ... Calculating Your Odds for Disease Science Education, published 17 Dez 2010  | doi:10.1289/ehp.scied011

▪    Do Noxious Neighbors Spread Disease? Bob Weinhold
Ecology and Wildlife Infectious Disease Invasive Species Do Noxious Neighbors Spread Disease? Bob ... Do Noxious Neighbors Spread Disease? ... play a role in the spread of human diseases News, published 01 Dez 2010  | doi:10.1289/ehp.118-a524

▪    A Reconsideration of Acute Beryllium Disease Kristin J Cummings, Aleksandr B Stefaniak, M Abbas Virji, Kathleen Kreiss
A Reconsideration of Acute Beryllium Disease Kristin ... A Reconsideration of Acute Beryllium Disease ... Kathleen Kreiss Division of Respiratory Disease Studies Research Article, published 28 Apr 2009  | doi:10.1289/ehp.0800455

▪    Dioxins and Cardiovascular Disease Mortality Olivier Humblet, Linda Birnbaum, Eric Rimm, Murray A Mittleman, Russ Hauser
and Cardiovascular Disease Mortality Olivier Humblet ... Dioxins and Cardiovascular Disease Mortality ... and cardiovascular disease (CVD) mortality in humans. Data Review, published 22 Jul 2008  | doi:10.1289/ehp.11579

▪    New Pathways to Disease Prevention David A Schwartz
Perspective New Pathways to Disease Prevention David ... New Pathways to Disease Prevention ... of this institute on the prevention of human disease Editorial, published 01 Feb 2007  | doi:10.1289/ehp.115-a68

usw. 


 

EERC-Led Study Addresses Critical Potential Public Health Risks Related to Pesticide Exposure

July 27, 2006
(GRAND FORKS, NORTH DAKOTA) -- Preliminary results of a project to reduce health risks from pesticide exposure, led by the Energy & Environmental Research Center (EERC) at the University of North Dakota (UND), verify that exposure to pesticides can induce pathological changes to the nervous system. The pesticide impact program is a  strategic effort between the EERC, the UND School of Medicine and  Health Sciences, the College of Nursing, the Psychology  Department, and several state and federal agencies.

The EERC team is evaluating how humans are exposed to pesticides so strategies can be developed to reduce health effects for at-risk populations.

"The results of this study are phenomenally relevant to our region and have global implications," said EERC Director Gerald Groenewold. "North Dakota is the perfect laboratory to perform this testing as the state's main industry is agriculture. Airborne pesticides are more prevalent in our state relative to other classes of pollutants, which makes their effects easier to detect." ....

More at http://www.undeerc.org

 


 

Alzheimer's disease with secondary Parkinson's syndrome.

Case report of a patient with dementia and Parkinson's syndrome after long-term occupational exposure to insecticides, herbicides, and pesticides][Article in German]
 Laske C, Wormstall H, Einsiedler K, Buchkremer G. Universitatsklinik fur Psychiatrie und Psychotherapie Tubingen.
Nervenarzt. 2004 Nov;75(11):1107-11.

This case report describes long-term occupational exposure to agricultural insecticides, herbicides, and pesticides as possible environmental risk factors of Alzheimer's disease (AD) and Parkinson's syndrome in a 59-year-old man. Initially the patient complained about disturbances in concentration, mnestic deficits, and problems finding words. In the further course of the disease, he developed Parkinson's syndrome with predominant hypokinesia and rigor in addition to mild-to-moderate dementia. Low levels of beta-amyloid 1-42 were found in the CSF. Electroencephalography showed left frontotemporal theta waves. Cranial MRI revealed general brain atrophy with a maximum biparietally. In cerebral positron emission tomography, general hypometabolism was found with maxima biparietally and left frontally. The possible differential diagnosis of AD and Parkinson's syndrome is discussed.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=15551110&query_hl=6&itool=pubmed_docsum
PMID: 15551110 [PubMed - indexed for MEDLINE]


 Uncalculated Risks in Some Pesticides, UCR Study Finds 

Some Compounds Show Dramatic Differences in Toxicity And Rate of Break Down Between Isomers
(January 13, 2005)

RIVERSIDE, Calif. – www.ucr.edu – Researchers at the University of California, Riverside have demonstrated that isomers – or the mirror-image structures – of some pesticides, although chemically identical, have very different biological and environmental impacts between the two sides. This may have significant implications for risk assessment and research and development directions of new products.

 


 

Abstract: Annual Review of Public Health Vol. 25: 1-24 (Volume publication date April 2004) (doi:10.1146/annurev.publhealth.25.101802.122951)
First posted online on November 3, 2003

Can Dementia Be Prevented? Brain Aging in a Population-Based Context

Mary N. Haan and ­Robert Wallace­
University of Michigan, School of Public Health, Epidemiology, Ann Arbor, Michigan 48104;
University of Iowa, Department of Preventive Medicine, Iowa City, Iowa 52240;

As a consequence of global aging of the human population, the occurrence of cognitive impairment and dementia is rapidly becoming a significant burden for medical care and public health systems. By the year 2020, the WHO predicts there will be nearly 29 million demented people in both developed and developing countries. Primary and secondary prevention of dementia through individual and population-level interventions could reduce this imminent risk. Vascular risk factors such as type 2 diabetes, hypertension, dietary fat intake, high cholesterol, and obesity have emerged as important influences on the risk of both vascular and Alzheimer's dementia. Understanding the reasons for differences between populations in genetic vulnerability and environmental exposures may help to identify modifiable risk factors that may lead to effective prevention of vascular and Alzheimer's dementia. ... http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.publhealth.25.101802.122951

 


  

Anmerkung Scherrmann:

Ich fände es wichtig,

- dass Schadstoffe als mögliche Ursache bei neurogenerativen Erkrankungen mehr im Fokus der Diskussion und Forschung stehen und

- dass Präventions-Maßnahmen im Sinne einer Schadstoff-Reduktion einen deutlich höheren Stellenwert in Wissenschaft, Politik und Gesellschaft bekommen.

 

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